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What the Research Shows The Arthritis Foundation says: Decades-old mouse studies reported that solanine damaged the gut lining and increased intestinal inflammation in colitis, a type of inflammatory bowel disease

Smokeless tobacco impairs healing and increases the risk of implant failure due to its effects on gum and bone health

Assuming youve ruled out any of the other causes (as below)
Bibcode:1988JIBeh...1..261V