history of tobacco in the united states commercial Tobacco in the American colonies
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In some ways, its very clear that pipe-weed is not meant as an obvious parallel for a real-world substance in the Lord of the Rings series

Planters frequently complained that their tobacco weighed much less in England that it did when it was inspected and weighed in the colony

Hill C., J.F

Similarly, complete healing was described after eight or ten days' treatment in a woman that had her face covered with a Ringworme rooted, as though she had a visor on her face, and a captain's son was cured of the king's euill (scrofula)
