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Further studies have shown that knocking down SIRT1 , 2 or 6 both in vivo and in vitro results in increased expression of NF - and simultaneous overexpression of inflammatory cytokines [145,146,147]
this effect was transient, as cough reflex sensitivity returned 24 h after EC use (50)
Experimental studies have shown that the use of electronic cigarettes can contribute to the development of cardiovascular changes
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