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Exposure to nicotine and the extent of its effects can also be influenced by individual differences in smoking behavior, metabolism, body mass index, and genetics

An independent review in Oklahoma has also questioned TSETs effectiveness

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Mills RF, Francini A, daRocha PSCF, Bacarini PJ, Krijger AM, GC, Williams LE, (2005) The plant P-1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels
