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Ask your doctor to check out any of the following symptoms: Chest discomfort or pain A persistent cough Repeated upper respiratory infections Trouble breathing or wheezing Blood in sputum Hoarseness Loss of appetite Unexplained weight loss Fatigue Swelling of face and/or neck veins Abdominal pain (non-smokers) Back pain (non-smokers) One broad but important rule of thumb is to know your body and watch for unusual changes and subtle warning signals