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doi: 10.1136/bmj.316.7139.1236 173 PierceJ

The induction of stemness in lung cancer, associated with e-cigarette use, was mediated through upregulation of a stemness marker SRY (sex determining region Y)-box 2 ( Sox2) , a gene that is highly expressed in stem cells and responsible for self-renewal along with the Yes associated protein 1/ E2F transcription factor 1/Octamer-binding transcription factor 4 ( Yap1 /E2F1/ Oct4) signaling axis [26]

For countries that ratified the FCTC in, for instance, 2006, it makes little sense to consider the trend in the number of current smokers since 1970 (ref

A sizable portion of that is likely related to the Massachusetts ban on flavored tobacco products