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Nicotines detrimental impact on the cardiovascular system is well documented (9), but pouches introduce nicotine directly into the bloodstream via oral absorption, bypassing pulmonary routes and potentially intensifying systemic effects (10)

Retrieved 14 April 2013

of Queensland, 2007)
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Human relevant NAMs have the potential to efficiently determine whether pre-market technologies should be abandoned due to specific hazard concerns, thereby avoiding unintended human health hazards that may only be identified during post-market surveillance
