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The meta-analytic tool overcomes many of the limitations of traditional meta-analyses by incorporating between-study heterogeneity into the uncertainty of risk estimates, accounting for small numbers of studies, relaxing the assumption of log(linearity) applied to the risk functions, handling differences in exposure ranges between comparison groups, and systematically testing and adjusting for bias due to study designs and characteristics

5ae and Supplementary Fig

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Given that the populations were typically unhealthy, this isnt enough to drive B12 recommendations, but it suggests that avoiding excess amounts is prudent