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UP-REGULATION OF nAChRs AND SYNAPTIC mGluRs IN PREFRONTAL CORTEX BY NICOTINE EXPOSURE DURING ADOLESCENCE A current hypothesis explaining why adolescents are more vulnerable to nicotine addiction is that nicotine has greater positive effects on adolescents than adults, whereas the negative effects associated with nicotine, such as withdrawal, are smaller in adolescents (ODell 2009)

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