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I thank you, Jerome, for that

Abbreviations ARE Antioxidant response element BBB Blood-brain barrier CDC Centers for Disease Control and Prevention CHI Closed head injury CNS Central nervous system CS Cigarette smoke 2DM Type 2 diabetes mellitus FTC Federal Trade Control GSH Glutathione GSSG Glutathione disulfide HO-1 Heme oxygenase 1 ISO International Organization for Standardization Keap1 Kelch-like ECH-associated protein 1 NF-B Nuclear factor kappa-light chain-enhancer of activated B cells NQO-1 NAD(P)H: quinone reductase I Nrf2 Nuclear factor erythroid 2-related factor OS Oxidative stress PECAM-1 Platelet endothelial cell adhesion molecule-1 ROS Reactive oxygen species SCSM Single cigarette smoking machine TBI Traumatic brain injury TJ Tight junction TS Tobacco smoke ZO-1 Zonulae occludentes-1 Authors contributions FS planned and performed the experiments, analyzed the data, and prepared the drafting of the manuscript