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Differential expression analysis Differential expression (DE) for each gene between various groups specified in the text that contain a mixture of smoking habits (i.e., between cell-type populations) was tested using a logistic regression (LR) test that contained smoking habit as a latent variable

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33 The guidance for those who provide stop-smoking support and advice is as follows: Advise there is not enough evidence to inform of the long-term harm of e-cigarettes Advise e-cigarettes are likely to be substantially less harmful than smoking Advise that use of e-cigarettes should be accompanied by complete cessation of tobacco smoking Discuss the duration the patient plans to use nicotine containing e-cigarettes Discuss using e-cigarettes long enough to prevent a return to smoking Discuss how to stop e-cigarette use when the patient is ready to