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Already, the tobacco men had been discussing among themselves what contingency measures they might have to adopt to head off a situation in which they might be forced by federal regulators to put a health warning on every kind of cigarette advertising, including print ads

This then leads to decreased apoptosis (i.e.programmed cell death), increased transformation and increased growth of small blood vessels

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non-smokers 24 , and the striatum is widely considered to be a key set of brain structures that support addiction 25,26,27 , with interactions between nicotine and the mesolimbic dopamine system also well-established (for a review see 28 )