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However, the lack of effect on total nicotine exposure indicates VLNC noncompliance, suggesting that smokers with SMI may respond to a reduced-nicotine standard by substituting alternative forms of nicotine." "Additional doseresponse relationships have been detected on the number of cigarettes smoked per day when low and high nicotine Spectrum cigarettes are available

Consistent with other studies, 46,5658 the particle size distribution (range of modes, 120165 nm) was similar to that of conventional cigarettes, with some e-cigarettes delivering more particles than conventional cigarettes (Figure 3)

Conventional programming and proven strategies for success must be willing to adapt and meet specific Tribal-community needs

Similar concerns should be raised about the new Newport non-menthol green variety introduced in 2025 that continues to signal that a characterizing flavor could be present