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In this review, we will focus on the latest research and elaborate on the clinical manifestations of HIT, including its manifestations in special populations such as atopic dermatitis (AD) and chronic urticaria (CU), as well as the latest understanding of its etiology and pathogenesis

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In the latter, additional confounders such as geographic site (Asians and North Americans have increased risk as compared with Europeans), association of anomalous pancreatobiliary malunion, and higher prevalence of gallstone disease, choledochal cyst, and gall bladder cancer in Asians

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