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Cancer Cell 21 , 105120 (2012)

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To synthesize these elements into a practical tool, Figure 5 summarizes a stepwise PKPD algorithm that starts from genotype-inferred metabolic capacity, explicitly accounts for phenoconversion, incorporates secondary pharmacodynamic markers, and uses TDM for continuous phenotype reassessment during antidepressant management

We summarize potential use by injury mechanism, therapeutic timing, route of administration, monitoring strategy, safety considerations, and evidence level