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10.1523/JNEUROSCI.1184-06.2006 64 LittermanN.IkeuchiY.GallardoG.O'ConnellB

37 concluded by analyzing solid tumors in TCGA that tissue inflammation lacking T cells occurred frequently in primary cancers including HCC, and they found a correlation between tumor intrinsic activation of Wnt/-catenin and non-T cell-inflamed TMEs

Second, the intricate crosstalk between the Wnt/-catenin pathway and other oncogenic signaling pathways, such as JAK/STAT and PI3K/Akt, underscores the need for combination therapies that target multiple pathways simultaneously

Ritt DA, Abreu-Blanco MT, Bindu L, Durrant DE, Zhou M, Specht SI, et al
