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This study also identified a rare variant encoding a truncated, putatitive loss-of-function FGF21 protein, associated with 7.5 mmHg higher blood pressure

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The article also notes that transcription factors, like NF-B and AP-1, which control inflammatory and apoptotic responses in cochlear cells, can be activated by hydrogen peroxide (H 2 O 2 ), a reactive oxygen species [34]