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Description
Dermatol Ther (Heidelb)
Improved insulin sensitivity: By modulating nicotinamide metabolism and influencing NNMT, the compound may reduce insulin resistance, thereby promoting better glucose management
Deficiency in vitamin B complex can lead to nerve damage or dysfunction, resulting in sensations like numbness, tingling, or a "pins and needles" feeling in the hands and feet
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
