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To illustrate, such a mechanism could lead to the activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), as suggested by Ohta (2023), which is known to be involved in oxidative stress responses (Yu et al., 2021) and involves a basic leucine zipper (bZIP) transcription factor
(F) The cell viability of IPEC-J2 cells was determined by CCK-8 assay in the Nrf2 pathway inhibition experiment
The liberation of Nrf2 from Keap1 allows Nrf2 accumulation and translocation to the nucleus (Cuadrado et al., 2019
Total ROS was measured following post-hoc Tukeys multiple-comparison test
