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This is achieved in an oxidation step mediated by PDI oxidoreductases (protein disulfide isomerases) [for details, see Lenzen (2017)].The ER acts as a H 2 O 2 store, keeping a greater amount of the generated H 2 O 2 in the ER due to a limited efflux of H 2 O 2 into the cytosolic space
Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors
doi: 10.1080/03601234.2020.1724660 173 AlsaudNShahbazKFaridM
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