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The peptide is primarily studied for targeted lipolysis the breakdown of stored triglycerides as well as adipose tissue metabolism, body composition endpoints, and more recently chondrocyte and cartilage repair models

Concomitant deficiencies (iron, folate), chronic illness, or drug interactions may blunt clinical response and warrant further evaluation

Early research into the structure-function relationships of the GH molecule identified the C-terminal region, specifically residues 176191 as a domain with particular relevance to metabolic activity in laboratory models

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