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doi: 10.1556/1886.2019.00016

This process may involve the p53 pathway (a known tumor suppressor) or the activation of other proapoptotic genes, resulting in programmed cell death (212)

Subsequently, another study also reported the melatonin ability to reduce the lipid peroxidation and improve the renal function during cyclosporine administration without compromising the effectiveness of cyclosporine.130 Stacchiotti conducted the electron microscopic analysis to reveal the effectiveness of melatonin to attenuate the cyclosporine-induced nephropathies at ultrastructural level.131 This morphometric study provided that melatonin alleviates the apoptotic nuclei, distended mitochondria, microvilli disruption, fused podocytes and glomerular basement membrane destructions in cyclosporine nephrotoxicity

doi: 10.1124/jpet.113.208223
