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Overall, the detection of cfDNA is a growing trend in cancer research and provides new opportunities for non-invasive diagnosis and prognosis of cancer

The prevalence now impacts 3%4% of the late-working population, with statistics in China ranging from 0.2% among individuals aged 55 to over 48% in those aged 95 and older (24)

To make the current evidence and gaps explicit, we now include Table 2 summarizing representative ferroptosis-in-AD studies (human, animal, and cellular), indicating which hallmarks were examined and whether selective rescue or checkpoint linkage was established (Bao et al., 2021

Through inflammatory cell infiltration (neutrophils, T/B cells), cytokine network imbalance, and vascular wall structural destruction, it ultimately leads to vascular stenosis, occlusion, or rupture, resulting in tissue and organ ischemia or hemorrhage (210, 211)