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The infection causes damage to cells and mitochondria, contributing to the development of symptoms

When uncertain, administer separately

Enzyme-linked immunosorbent assay (ELISA) For the in vivo cytokine experiment, the hippocampus, prefrontal cortex, and amygdala of mice were obtained at day 5 postsurgery, or at 3 h after scopolamine or vehicle treatment after the neurobehavioral tests

Owing to the pronounced mutagenicity and the carcinogenic potential of many NAs, NA impurities in pharmaceuticals are designated as a "cohort of concern" under the ICH M7(R2) guideline, for which the corresponding Threshold of Toxicological Concern (TTC) approach is not considered appropriate (European Medicines Agency 2025)