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Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD

Platelet counts and concentrations of fasting blood sugar (FBS), hemoglobin A1c (HbA1c), immunoreactive insulin (IRI), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, non-esterified fatty acids (NEFA), aspartate aminotransferase (AST), ALT, -glutamyl transpeptidase, ferritin, and type IV collagen 7 were measured using standard laboratory techniques before and after glutathione treatment

However, in Alzheimers and other neurodegenerative diseases, P35 is cleaved into a smaller protein called P25, which can also bind to CDK5 but has a longer half-life than P35

Reduced glutathione (GSH) is the active, working form of glutathione