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ER activation of Akt and MAPK pathways is also thought to underlie E2-mediated protection of muscle against age-induced sarcopenia (239245), exercise-induced muscle damage (227, 241, 246, 247), and myocyte apoptosis in response to a variety of cellular perturbations (248251)
There is a need to confirm the above-mentioned research results, as well as to thoroughly investigate the role of angiostatin in neurodegeneration, especially in preventing the development of these processes
