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Proton nuclear magnetic resonance spectroscopy analysis reveals differential expression of phosphocreatine, glutamate and GABA in the EC of anesthetized aged APOE4 mice 1 H NMR spectroscopy provides simultaneous quantification of the concentration of several highly abundant metabolites in the brain, including neurotransmitters such as glutamate and gamma-aminobutyric acid (GABA), as well as other biological metabolites such as creatine, glutathione, and N-acetylaspartate (NAA)

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Following this, epidemic cases of ME/CFS were described as mass hysteria in 1970 by two psychiatrists, McEvedy and Beard (535)