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Description
Zaldumbide (Leiden University Medical Center, the Netherlands)

Exposure to stress resulted in diminished hippocampal brain-derived neurotrophic factor (BDNF) expression in the CA3 region of neurons, a decrease in exploratory behavior, an increase in fecal output, and heightened levels of neuronal nitric-oxide synthase (nNOS), all of which are indicative of neural impairment (72)
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score 4 (severe), multiple large foci or diffuse area of necrosis [21,22,23,61]
