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Description
Stratification ensures that the proportion of toxic and non-toxic classes is approximately the same in the full dataset and both splits
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10.1001/archinte.165.10.1167
The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
