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NRF2 is the master switch of the cellular antioxidant response: when oxidative stress is sensed, KEAP1 (the NRF2 repressor) is oxidized at critical cysteine residues, releasing NRF2 for nuclear translocation and ARE-driven upregulation of the complete antioxidant gene set including GCLC, GCLM, GSR, GPX1, GSTP1, and the thioredoxin system

Nevertheless, future clinical trials should be conducted to explore the in vivo effects of indomethacin in patients during various stages of M.tb infection

Cell Metab 23(1):6376 [DOI] [PMC free article] [PubMed] [Google Scholar] 117.Ma R, Ji T, Zhang H, Dong W, Chen X, et al
The vertebral body formation begins early in embryonic development and continues with differentiation and mineralization until e19 (84)
