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doi: 10.1016/j.bcp.2024.116565

An updated Cochrane review in 2019 of four studies with 907 participants was very uncertain as to if ALC caused a pain reduction after 6 to 12 months of treatment

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However, the DiNicolantonio's study did not examine the effect of varying L-carnitine dosing on all-cause mortality or adverse cardiovasular outcomes
