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The liver is also responsible for the activation of the vitamin Kdependent factors II, VII, IX, and X and protein C

This helps explain why patients with extensive surgical trauma or prolonged ischemia often develop a systemic inflammatory response that parallels septic shock, even in the absence of infection ( Importantly, these pathways offer targets for intervention: blocking upstream mtDAMPs release or downstream receptors could blunt the harmful inflammation

Physiologia Plantarum 154, 142161

Acetyl-CoA then combines with oxaloacetate forming citrate, which exits the mitochondria to proceed toward fatty acid synthesis in the cytosol