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Description
NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models
Patients with high NNMT levels tend to have poor prognostic parameters and overall survival (OS) and disease-free survival (DFS) (26, 27, 45)
But they are animal and cell work
It is imperative to note that while these effects suggest a potential benefit, further research is needed to clarify the relationship between NAD + and hypertension
