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Methods Ethics statement All animal experiments were approved by the UNC Institutional Animal Care and Use Committee (IACUC protocol ID: 24-029.0)

Research Applications (Sema Benefits) Sema has been the subject of a wide range of non-clinical and preclinical studies exploring its effects on energy regulation, glucose metabolism, and hormonal pathways

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer

Next-Generation Signal Peptides The broader signal-peptide field is expanding toward designed analogs, PEGylated derivatives, and copper-coordinating analogs of GHK that may modify pharmacokinetics or stability