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A tracer study using (U- 13 C 6 ) glucose and dialyzed FBS revealed that the biosynthesis of purine metabolites, such as inosine monophosphate (IMP), AMP, and ATP, is increased in Keap1 -knockout MEFs and decreased in their Nfe2l2 -knockdown counterparts [35]

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To understand why that matters, it helps to look at All About Liposomes

164 Both proteins harbor a carbohydratebinding globular lectin domain with a prolinerich, hookshaped Pdomain that projects into the lumen and tethers folding catalysts such as ER proteindisulfide isomerases and peptidylprolyl isomerases