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In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs
This coexpression technology, SNORCL, is an example of how the functional diversity of oxygen-related enzymes in all kingdoms of life can be taken advantage of for oxygen delivery if appropriate candidates are identified
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