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This approach works well for prevention and for treating mild to moderate deficiency

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Functional enzyme coupling Since free fatty acids and oxygenated eicosanoids and related PUFAs can rapidly diffuse out of the cell 1,35 or become reincorporated within membrane lipids, and since activated PLA 2 s are concentrated at specific organelle interfaces, free arachidonic acid and other fatty acid concentrations exist as gradients that restrict most downstream eicosanoid metabolism only to sites in very close proximity to PLA 2 activity

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