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However, physiological concentrations of 1 to 10 mg/mL peptide were measured in leukocytes and in the lumen of crypts of Lieberkhn and have been shown to kill microorganisms in vitro at physiological salt concentrations [132]

Eligible patients had RRMM after 2 prior lines of therapy and presented measurable disease, defined as serum monoclonal protein 5 g/L or serum free light chain 100 mg/L with an abnormal kappa-to-lambda ratio

It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug/Laboratory Test Interactions), use of a gluten free diet in nontropical sprue, or administration of antibiotics in tropical sprue

Only a very small amount of expression of TGF- 1 was detected in normal vein samples