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Certain genes are confirmed to be associated with the familial occurrence of PD by neuropathological examination and family-based genome-wide association studies (GWAS)

In light of the recent findings that melatonin combined with conventional anti-cancer therapy could limit the adverse effect of chemotherapy and increase its therapeutic efficacy, including reducing drug resistance [159,160,161,162,166,167], its simultaneous use with DNMT inhibitors or other epigenetic drugs may be a more efficient approach to avoid the limitations of epigenetic drugs

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O 2 - radicals are produced when electrons from NADPH produced in the pentose phosphate pathway are converted to molecular oxygen (O 2 ) in extracellular fluid or inside phagosomes