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Statistical analysis All outcomes except body mass were analyzed using two-way analysis of variance (ANOVA) with group and age specified as between-subjects factors

In a first-in-human Phase I study (NCT01773018) in patients with locally advanced or metastatic solid tumors, savolitinib showed signs of clinical efficacy in CRC tumor type

FIGURE 2 Molecular docking is a prediction technology for biomolecular interactions based on the lock-and-key principle and induced fit theory, which quickly predicts the binding conformations of ligands and receptors through geometric matching and energy optimization algorithms (Patel et al., 2024)

Top panels illustrate mechanisms of action: atropine (2.1 mg) competitively antagonizes acetylcholine at muscarinic receptors to reverse cholinergic effects (e.g., bronchorrhea, bronchospasm, bradycardia), while pralidoxime (2PAM, 600 mg) reactivates acetylcholinesterase by cleaving the nerve agentenzyme bond prior to irreversible aging. Middle panels depict the dualchamber autoinjector design, which contains atropine and pralidoxime in separate compartments and delivers both drugs sequentially via a springloaded intramuscular mechanism from a single needle