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Description
Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels
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5-Amino-1MQ works by inhibiting NNMT, the enzyme that methylates nicotinamide (a precursor to NAD+) and sends it toward excretion rather than recycling into energy pathways
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