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127 A large, questionnaire-based, observational study that included data from 34,576 subjects between 40 and 69 years of age upon enrollment found that those who ate diets high in vitamin D, fruits and vegetables, and protein had lower odds of reporting hearing difficulty, while those who ate high-fat diets were more likely to report hearing problems

Methylmalonic acid is generally the more B12-specific marker, while homocysteine and the other markers are best interpreted with kidney function and folate status in mind

Moreover, calcium-binding proteins play a vital role in modulating oxidative stress and inflammatory responses, two major contributors to neurodegenerative processes [184]

There was also a significant increase in the levels of TGF- in these individuals