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By contrast, megadose, non-targeted antioxidants (blanket vitamins or generic scavengers) typically underperform because they ignore source identity and compartment, pool signals much like bulk Amplex-style readouts and suppress adaptive redox cues essential for resilience and recoveryhence the preference for node- and compartment-aware strategies that are titrated to objective redox biomarkers rather than applied indiscriminately (Le Gal et al

9 A 2024 Cochrane review for COPD found little to no changes in exacerbation rates, lung capacity, or quality of life with supplementation

Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Yi D., Hou Y., Tan L., Liao M., Xie J., Wang L., Ding B., Yang Y., Gong J