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However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body's endogenous antioxidant system is not able to effectively remove excessive ROS production[2]

doi: 10.1073/pnas.0530251100

All that said, if youre focused on your kidney health and still want to enjoy your daily cup of coffee, keep in mind that what you add to your brew can be more of a concern than coffee on its own

Bioassay Technology Laboratory, catalog number: E1642 Hu/China/) with a sensitivity of 0.05 ng/mL