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These prescribing patterns were noted in patients without specific contraindications, though opioids were seen more in patients with a history of gastroesophageal reflux
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101, 871874 10.1111/1523-1747.ep12371709 [DOI] [PubMed] [Google Scholar] 86.Arjinpathana N
Therefore, their use together with a slight modification of the parent compounds structure can lead to the desired therapeutic profile, including a low risk of serious clinically important side effects
