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The peroxisome-induced formation of oxidants is important for the degradation of cellular components and autophagy

Knocking out Nrf2 in these transgenic mice resulted in accelerated motor neuron loss and astrocytic proliferation, and led to earlier disease onset and shorter lifespan [238]

Furthermore, quantification of hepatocellular vacuolation (a characteristic of cellular degeneration observed through tissue pathology staining) at the 2-h time point revealed a 1.5-fold greater area of liver degeneration in hepsin / mice compared with wild-type mice, which increased to ~ 2.5-fold greater by the 6-h time point (Fig

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