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doi: 10.1074/jbc.M608361200

The Critical Problem: No Human Clinical Evidence As of early 2026, not a single randomized controlled trial (RCT) has been completed and published for human musculoskeletal indications

Leptin, secreted by adipose tissue and gastric mucosa in response to energy store availability, binds to the leptin receptors in macrophages, promoting phagocytosis and the production of pro-inflammatory and pro-fibrotic cytokines such as IL-1, Il-18, and TGF- [88]

Suppliers should provide clinical testing data demonstrating even depigmentation effects