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Description
These proteins form what is called an apoptotic blockade, meaning that cells cannot undergo apoptosis, even when they experience DNA damage that would normally trigger cell death
Phenotypes resembling human ALS have been successfully replicated in SOD1 mutant mice and through the targeted deletion of the hypoxia response element (HRE) from the promoter of the mouse VEGF gene (Thakur et al
doi: 10.1080/10715760802337273
Kim YK, Kim OY, Song J
