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Similar results were obtained in cultured B16F10 melanoma cells where AC reduced levels of tyrosinase, tyrosinase-related protein-1 (TRP-1), and microphthalmia-associated transcription factor (MITF) proteins by activating extracellular signal-regulated kinase (ERK) signaling (Son et al

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Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis

Oral administration of Lactobacillus pentosus GMNL-77 significantly decreased the interleukin (IL)-23/IL-17A axisassociated cytokines and erythematous scaling lesions in the skin of IMQ-treated mice, suggesting that artificial alteration of the gut microbiota might be relevant for reducing the systemic inflammatory response in the skin of psoriasis patients (Chen et al., 2017)