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The factors contributing to this profound modulation of thiol pKa's are under, which so profoundly modulate thiol pKa's, are under active investigation, and include solvation, electrostatic effects with neighboring charges and dipoles, as well as H-bonding interactions [5-7]
Even the small folate cycle can only proceed to a limited extent because the supply of THF from the large folate cycle is no longer given
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